Which chemotherapy agent is used for treatment of transmissible venereal tumor (TVT)?

Which chemotherapy agent is used for treatment of transmissible venereal tumor (TVT)?

• A. Doxorubicin
• B. Cyclophosphamide
• C. Vincristine
• D. Methotrexate

Answer: (C)

Transmissible venereal tumor is a contagious canine cancer that often responds very well to chemotherapy. The preferred treatment is vincristine, a vinca alkaloid that blocks microtubule formation by binding tubulin, which stops cell division during mitosis. This mechanism leads to rapid tumor shrinkage and a high likelihood of complete remission when given as a short course of weekly IV doses. Vincristine typically has a favorable safety profile, allowing outpatient treatment. Other chemotherapeutic drugs like doxorubicin, cyclophosphamide, or methotrexate can be used in different cancers, but they don’t offer the same combination of high efficacy and tolerability for TVT as vincristine.

Transmissible venereal tumor is a contagious canine cancer that often responds very well to chemotherapy. The preferred treatment is vincristine, a vinca alkaloid that blocks microtubule formation by binding tubulin, which stops cell division during mitosis. This mechanism leads to rapid tumor shrinkage and a high likelihood of complete remission when given as a short course of weekly IV doses. Vincristine typically has a favorable safety profile, allowing outpatient treatment. Other chemotherapeutic drugs like doxorubicin, cyclophosphamide, or methotrexate can be used in different cancers, but they don’t offer the same combination of high efficacy and tolerability for TVT as vincristine.